姓名:黎迎
工作单位:中国医学科学院药用植物研究所
职称/职务:副研究员
E-mail: yli@implad.ac.cn
基本情况:
黎迎,女,汉族,1989年4月生,山东省菏泽人,博士,副研究员,硕士研究生导师,主要从事中药新型给药系统和新技术研究,并从事新药、保健食品、药妆等产品研发工作。
2016年在北京协和医学院获得博士学位,同年加入中国医学科学院药用植物研究所制剂中心。2019-2021年在麻省理工学(Massachusetts Institute of Technology, MIT)Robert S. Langer教授(美国最年轻三院院士,2021年增选为中国工程院外籍院士)课题组从事博士后研究。兼任聊城大学学报编委,J Biomed Nanotechnol、Tisue Eng Regen Med和Pharmaceutical fronts杂志审稿人,以及中华中医药学会青年委员会委员和中国中药协会人参属药用植物研究发展专业委员会委员。主持中央高校基本科研业务费项目《DSPE-PEG-胆酸修饰盐酸阿霉素/水飞蓟宾口服肝靶向脂质体研究》(2017350017) ,中央高校基本科研业务费项目《基于鞣质的自组装酶响应多功能黏附递药系统构建与评价》(3332021051)。参与十三五国家重点研发计划、北京市自然科学基金、十三五和十四五中国医学科学院医学与健康科技创新工程项目。受国家市场监督管理总局委托,参与《保健食品原料目录 人参》和《保健食品原料目录 西洋参》的起草编纂。申请发明专利3项。在J Antimicrob Chemoth、Molecules、Int J Nanomed、J Biomed Nanotechnol、Drug Des Dev Ther等期刊发表学术论文40余篇。
主持项目:
(1)中央高校基本科研业务费:《基于鞣质的自组装酶响应多功能黏附递药系统构建与评价》15万 2021.1-2022.12 主持 3332021051
(2)中央高校基本科研业务费:《DSPE-PEG-胆酸修饰盐酸阿霉素/水飞蓟宾口服肝靶向脂质体研究》15万 2017.4-2018.12.主持 2017350017
(3)与企业合作项目:《不同基质配方对关节镇痛巴布膏的黏性的影响研究》20万 2020.10-2023.1主持
(4)与企业合作项目:《胃力康颗粒工艺改进开发研究》15万 2021.3-2023.3主持
代表性成果:
[1] Chenyang Wu, et al., Ying Li*, Zhengqi Dong*. Effect and Mechanism of Pharmaceutical Excipients on Berberine to Alleviate Ulcerative Colitis via Regulating Gut Microbiota Molecules. 2022; 27(18): 5997.
[2] Samantha Palace, Kyra E Fryling, Ying Li, et al. Identification of bile acid and fatty acid species as candidate rapidly bactericidal agents for topical treatment of gonorrhea J Antimicrob Chemoth. 2021; doi:10.1093/jac/dkab217.
[3] Ying Li, Chunyan Zhu*. Development and In Vitro and In Vivo Evaluation of Microspheres Containing Sodium N-[8-(2-hydroxybenzoyl)amino]caprylate for the Oral Delivery of Berberine Hydrochloride Molecules. 2020; 25: 1957.
[4] Ying Li, Dandan Yang, Yian Wang, et al. Co-delivery doxorubicin hydrochloride and silybin for anti-hepatoma via enhanced oral hepatic targeted efficiency Int J Nanomed. 2019;14: 301–315.
[5] Ying Li, Yi-Qun Song, Chun-Yan Zhu*. Effect of bioadhesive excipients on absorption mechanism of Pueraria Flavonid transporting across the Caco-2 cell monolayer Chinese herbal medicines. 2019;11: 78–85.
[6] Ying Li, Dandan Yang, Chunyan Zhu*. Impact of Sodium N-[8-(2-Hydroxybenzoyl)amino]- caprylate on Intestinal Permeability for Notoginsenoside R1 and Salvianolic Acids in Caco-2 Cells Transport and Rat Pharmacokinetics Molecules. 2018; 23(11): 2990.
[7] Ying Li, Chunyan Zhu*. Mechanism of hepatic targeting via oral administration of DsPe–Peg–cholic acidmodified nanoliposomes Int J Nanomed. 2017; 12: 1673–1684.
[8] Ying Li, Dandan Yang, Yun Zhang, et al. Novel DSPE-PEG-cholic acid-modified liposomes with hepatic targeting properties improve the anti-tumor efficacy of oral doxorubicin hydrochloride for liver tumor-bearing mice J Biomed Nanotechnol. 2017; 13:727-736.
[9] Li Ying, Zhang Yun, Zhu Chunyan*. Pharmacokinetics and correlation between in vivo absorption and in vitro release of panax notoginseng saponins bio-adhesive pellets Chin Nat Medicines. 2017; 15(2): 142-151.
[10]Ying Li, Chunyan Zhu*. Enhanced hepatic targeted delivery via oral administration using nanoliposomes functionalized with novel DSPE-PEG-cholic acid conjugate RSC Advances. 2016; 6(33): 28110 – 28120.
[11] Limei Zhang#, Ying Li#, Yun Zhang, et al. Sustained release of isoniazid from polylactide microspheres prepared using solid/oil drug loading method for tuberculosis treatment Sci China Life Sci. 2016; 59(7): 724–731.
[12] Jieyun Huang#, Zhi Chen#, Ying Li, et al. rifapentine-linezolid-loaded Plga microspheres for interventional therapy of cavitary pulmonary tuberculosis: preparation and in vitro characterization Drug Des Dev Ther. 2017;11: 585–592.
#共同第一作者,*通讯作者