姓名:栾广祥
工作单位:青海大学医学部药学系
职称/职务:副教授,药学系主任助理
E-mail:luanguangxiang1990@126.com
基本情况:
栾广祥,男,汉族,1990年2月出生,山东聊城人,博士,副教授,硕士研究生导师。主要从事青藏高原地区药用特色生物资源中调节糖脂代谢药物的研究与开发工作:(1)低氧胁迫对糖脂代谢的影响及机理研究;(2)青藏高原特色生物资源中调节糖脂代谢及抗缺氧活性成份的发现和制备工艺研究;(3)调节糖脂代谢及抗缺氧先导活性成分的药效学及机制研究。
主持青海省自然科学基金1项,青海大学青年项目2项,青海大学省部共建三江源与高原农牧业国家重点实验室自主课题1项,青海省青稞遗传育种重点实验室开放基金1项,青海大学医学院青年项目1项,参与国家及省部级科研项目7项。在Journal of Agricultural and Food Chemistry、Food Chemistry、Oxidative Medicine and Cellular Longevity、Journal of Separation Science等杂志发表论文论文18篇,申请国家发明专利10余项,授权专利2项,完成青海省科技成果3项。入选2020年青海省“昆仑英才.高端创新创业人才”拔尖人才。
主持或参与科研项目情况:
1.青海省科技厅,自然科学基金项目,2022-ZJ-945Q,蕨麻改善低氧胁迫下胰岛素抵抗的物质基础及作用机理研究,2022-01至2024-12,15万元,主持。
2.青海大学国家重点实验室自主课题:高浓度FFA对C2C12骨骼肌细胞糖代谢损伤及蕨麻保护作用研究,2021-ZZ-06,2021.7.20-2023.7.20,10万,主持。
3.青海大学青年基金,青藏高原蕨麻化学成分分析及改善胰岛素抵抗作用研究,2020-QYY-7,2020.12-2022.12,5万,主持。
4.青海大学医学部中青年科研基金项目,蕨麻三萜类成分制备及其改善T2DM作用研究(团队项目),2024.01-2026.12,6万,主持。
5.青海省青稞遗传育种重点实验室开放基金,青稞高产β-葡聚糖优异种质资源的筛选,2023.09-2025.12,主持。
6.青海大学医学院中青年科研基金项目,青藏高原蕨麻化学成分分析及改善胰岛素抵抗活性成分研究,2020-kyy-1,2021-1至2022-12,5万元,主持。
7.国家自然科学基金委员会,地区基金,海尔特兹树莓矢车菊素类化合物激活 AMPK 改善胰岛素抵抗的机制研究,2023.01-2016.12,32万元,参与。
8.国家自然科学基金委员会,面上项目,31870333,马蔺子低聚茋类化合物调节胰岛素抵抗脂肪细胞脂代谢的机制研究,2019.01至2022.12,60万,参与。
9.青海省科技厅,科技合作专项,2018-NZ-812,靶向AMPK干预2型糖尿病的青藏特色活性物质发现及作用机制研究,2018-7至2020-12,49万元,参与。
10.中国科学院,中科院战略性先导专项,XDA12040320,基于线粒体代谢重编程治疗糖尿病的青藏特色资源中先导化合物发现,2017.01至2018.12,100万元,参与。
代表性论文:
1. Luan Guangxiang; Wang Yuwei; Wang Zhenhua; Zhou Wenna; Hu Na; Li Gang; Wang Honglun; Flavonoid glycosides from fenugreek seeds regulate glycolipid metabolism by improving mitochondrial function in 3T3-L1 adipocytes in vitro, Journal of Agricultural and Food Chemistry, 2018, 66(12): 3169-3178.
2. Guangxiang Luan; Linlin Li; Hongxia Yue; Yongfang Li; HuilingLv; Yuwei Wang ; Phenols from Potentillaanserina L. Improve Insulin Sensitivity and Inhibit Differentiation in 3T3-L1 Adipocytes in Vitro, Chemistry & Biodiversity, 2023, 20: e202200784.
3. Luan, G.; Yang, M.; Nan, X.; Lv, H.; Liu, Q.; Wang, Y.; Li, Y. Optimization and Comparative Study of Different Extraction Methods of Sixteen Fatty Acids of Potentillaanserina L. from Twelve Different Producing Areas of the Qinghai-Tibetan Plateau. Molecules, 2022, 27, 5443.
4. Guangxiang Luan; Yuwei Wang; Jian Ouyang; Yanfeng He; Wu Zhou; Qi Dong; Honglun Wang; Na Hu ; Stabilization of LyciumruthenicumMurr. anthocyanins by natural polyphenol extracts, Journal of Food Science, 2021, 86(10): 4365-4375.
5. Yuwei Wang; Guangxiang Luan; Wu Zhou; Jing Meng; Honglun Wang; Na Hu; Yourui Suo ; Subcritical water extraction, UPLC-Triple-TOF/MS analysis and antioxidant activity of anthocyanins from LyciumruthenicumMurr, Food Chemistry, 2018, 249: 119-126.
6. Yuwei Wang; Guangxiang Luan; Wu Zhou; Jinmao You; Na Hu; Yourui Suo ; 2-(4-Amino)-Phenyl- 1-Hydrogen-Phenanthrene [9,10-d] Imidazole as a Novel Fluorescent Labeling Reagent for Determinat ion of Fatty Acids in Raspberry, Food Analytical Methods, 2017, 11(2): 451-465.
7. Luan Guangxiang; Li Gang; Ma Xiao;JinYoucai; Hu Na; Li Ji; Wang Zhenhua; Wang Honglun; Dexamethasone-Induced Mitochondrial Dysfunction and Insulin Resistance-Study in 3T3-L1 Adipocytes and Mitochondria Isolated from Mouse Liver, Molecules, 2019, 24(10): 1982.
8. Luan Guangxiang; Tie Fangfang; Yuan Zhenzhen; Li Gang; He Jie; Wang Zhenhua; Wang Honglun;Hypaphorine, an Indole Alkaloid Isolated from Caragana korshinskiiKom., Inhibites 3T3‐L1 Adipocyte Differentiation and Improves Insulin Sensitivity in Vitro,Chemistry & biodiversity, 2017, 14(7): e1700038.
9. Luan Guangxiang; Wang Honglun;LvHuanhuan;Hu Na; Suo Yourui; Wang Xiaoyan; Separation and purification of five flavone glucosides and one lignan from caragana korshinskiikom. By the combination of hsccc and semi-preparative RPLC,Chromatographia, 2016, 79(13-14): 823-831.
10. Li Gang#; Luan Guangxiang#; He Yanfeng;Wang Zhenhua; Suo Yourui; Ma Chenjun; Wang Honglun; Polyphenol Stilbenes from Fenugreek (Trigonellafoenum-graecum L.) Seeds Improve Insulin Sensitivity and Mitochondrial Function in 3T3-L1 Adipocytes,Oxidative Medicine and Cellular Longevity, 2018, DOI: 10.1155/2018/7634362.
11. Zhang Qiulong#;Luan Guangxiang#; Ma Tao; Hu Na; Suo Yourui; Wang Xiaoyan; Ma Xiaofeng; Ding Chenxu; Application of chromatography technology in the separation of active alkaloids from Hypecoumleptocarpum and their inhibitory effect on fatty acid synthase, Journal of Separation Science, 2015, 38(23): 4063-4070.
授权发明专利:
1. 丁晨旭; 马晓丰; 王小艳; 张秋龙; 栾广祥; 索有瑞; 苄基异喹啉类生物碱的新用途, 2018-03-13, 中国, ZL201510496303.1.
2. 王洪伦; 栾广祥; 马筱; 索有瑞; Application of isoorientin in the preparation of insulin-resistant related disease, 2018-10-18, 澳大利亚, 2018101555.